Induced Fit Movements and Metal Cofactor Selectivity of Class II Aldolases
نویسندگان
چکیده
منابع مشابه
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.
Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are class I enzymes, structural studies to date have focused primarily on the class II KARIs, which arose through domain duplication. In the present study, we present five new crystal structures of class I KARIs. These include the first structure of a KARI with a six-residue β2αB (cofactor sp...
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Introduction: This in vitro study investigates the marginal and internal fit of indirect class II composite restorations. Two different processes for chair-side restorations were compared. In group A, the restorations were fabricated using CAD/CAM technology (Cerec, Sirona, Germany, Bernsheim) and in group B they were made by hand (GrandioSO Inlay System, VOCO GmbH, Germany, Cuxhaven). Methods:...
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Adenylate kinases have an M(r) around 23,000 which classifies them among the smallest phosphoryl group transferring enzymes. In order to prevent phosphoryl transfer to water, i.e. hydrolysis, these enzymes undergo induced-fit motions on substrate binding and assemble/disassemble their catalytic centres during each reaction cycle. Details of these processes have been derived from several X-ray s...
متن کاملinternal and marginal fit of modern indirect class ii composite inlays
introduction: this in vitro study investigates the marginal and internal fit of indirect class ii composite restorations. two different processes for chair-side restorations were compared. in group a, the restorations were fabricated using cad/cam technology (cerec, sirona, germany, bernsheim) and in group b they were made by hand (grandioso inlay system, voco gmbh, germany, cuxhaven). methods:...
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Transition metal-transporting P1B-type CPx ATPases play crucial roles in mediating metal homeostasis and resistance in all cells. The degree to which N-terminal metal binding domains (MBDs) confer metal specificity to the transporter is unclear. We show that the two MBDs of the Zn/Cd/Pb effluxing pump Anabaena AztA are functionally nonequivalent, but only with respect to zinc resistance. Inacti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m311375200